Regulation of breast cancer stem cell activity by signaling through the notch 4 receptor

Clinical trials using Seward Stomacher® 80

The Stomacher® 80 was used to blend solid tumors for 12 minutes.
Notch receptor signaling pathways play an important role not only in normal breast development but also in breast cancer development and progression. We assessed the role of Notch receptors in stem cell activity in breast cancer cell lines and nine primary human tumor samples. Our findings suggest that Notch4-targeted therapies will be more effective than targeting Notch1 in suppressing breast cancer recurrence, as it is initiated by breast cancer stem cells.

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