Regulation of breast cancer stem cell activity by signaling through the notch 4 receptor

The Stomacher® 80 was used to blend solid tumors for 12 minutes.

Notch receptor signaling pathways play an important role not only in normal breast development but also in breast cancer development and progression. We assessed the role of Notch receptors in stem cell activity in breast cancer cell lines and nine primary human tumor samples. Our findings suggest that Notch4-targeted therapies will be more effective than targeting Notch1 in suppressing breast cancer recurrence, as it is initiated by breast cancer stem cells.

clinical cytology oncology breast cancer stomacher 80

Genotoxic activity in human faecal water and the role of bile acids: a study using the alkaline comet assay

Faecal samples were collected and kept on ice before processing. Samples
were homogenized in a stomacher for 2 minutes in a Stomacher® 400.

The results of the present study indicate that the comet assay provides a powerful tool to investigate the genotoxicity of faecal water samples in a human colonic tumour cell line.

clinical chemistry oncology faeces bile acids stomacher 400