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Effects of Reproductive Hormones on Experimental Vaginal Candidiasis

The Stomacher was used to process genitourinary tissue in an investigation of vulvovaginal candidiasis (VVC). This is an opportunistic mucosal infection caused by Candida albicans that affects large numbers of otherwise healthy women of childbearing age.

Acute episodes of VVC often occur during pregnancy and during the luteal phase of the menstrual cycle, when levels of progesterone and estrogen are elevated.

Although estrogen-dependent experimental rodent models of C. albicans vaginal infection are used for many applications, the role of reproductive hormones and/or their limits in the acquisition of vaginal candidiasis remain unclear. This study examined the effects of estrogen and progesterone on several aspects of an experimental infection together with relative cell-mediated immune responses.

Results showed that while decreasing estrogen concentrations eventually influenced infection-induced vaginal titers of C. albicans and rates of infection in inoculated animals, the experimental infection could not be achieved in mice treated with various concentrations of progesterone alone.

mycology candida mouse genitourinary tract stomacher 80